Messages

Worms?

Happy birthday luisdementia!

That looks like Robin Williams, but I can't for the life of me recognize the film.

Hugo's House of Horrors?
Or one of its sequels?

Guardians of the Galaxy?

Space Quest 0: Replicated?

One of the Peanuts games?

Where In The World Is Carmen Sandiego?

Yay, you got it!
Although now I don't get to share that other screenshot I had planned.

Doesn't look familiar. Is it an AGS game?

Nope, it's actually a fairly popular game. It's been ported to just about every system I can think of.

EDIT:
Just to demonstrate that, here's another cropped screenshot of the same game on a completely different system.
[imgzoom]http://orig00.deviantart.net/6c8f/f/2016/327/c/e/name_the_game_screenshot_25_by_danvzare-dapc24h.png[/imgzoom]

Correct!

Holy crap!
I've never even played the game. I only made that guess because the author of a webcomic I read, never shuts up about the game. And since I knew it was a C64 game, and you showed a picture with a ball in it, I just made a complete guess.
Maybe I looked up the game at one point, and subconsciously remembered the title screen.

[imgzoom]http://orig06.deviantart.net/9cba/f/2016/326/5/b/name_the_game_screenshot_24_by_danvzare-dap8r50.png[/imgzoom]

Wizball?

Where in Time is Carmen Sandiego?

Kings Quest IV?

King's Quest III?

[HAPPY BIRTHDAY CHRIS!!!]

HAPPY BIRTHDAY CHRIS!!!

Charles Cecil: Legend Of The Gobbos?

Charles Cecil?

You got the subtitle right though, so I'm guessing you know the game. Over to you.

Mrs. Doubtfire?

James Pond?

Nope.
I honestly thought someone would have recognized these cute little guys by now. The game must have been much more obscure than I first thought.

Seriously?
Not a single guess?

Guess I need to post another screenshot then.
[imgzoom]http://orig02.deviantart.net/387d/f/2016/323/f/1/name_the_game_screenshot_23_by_danvzare-daox5dw.png[/imgzoom]